| First Author | Skow LC | Year | 1985 |
| Journal | Genetics | Volume | 110 |
| Issue | 4 | Pages | 723-32 |
| PubMed ID | 2993101 | Mgi Jnum | J:7973 |
| Mgi Id | MGI:56442 | Doi | 10.1093/genetics/110.4.723 |
| Citation | Skow LC, et al. (1985) The locus encoding alpha A-crystallin is closely linked to H-2K on mouse chromosome 17. Genetics 110(4):723-32 |
| abstractText | We have used a complementary DNA (cDNA) for mouse alpha A-crystallin to probe genomic DNA for restriction fragment length polymorphisms which could be used to map the alpha A-crystallin gene locus (Acry-1) in the mouse genome. Ten of 12 restriction endonucleases produced fragment polymorphism among various inbred strains of mice. A comprehensive strain survey conducted with six endonucleases resulted in the discovery of six allelic forms of Acry-1. Linkage analysis was conducted on DNA from three sets of recombinant inbred strains of mice and demonstrated close linkage of Acry-1 with the major histocompatibility complex (H-2) on chromosome 17. Analysis of congenic and recombinant congenic strains of mice confirmed the linkage of Acry-1 and H-2 and located the alpha A gene to the region between glyoxylase (Glo-1) and H-2K. |
