Primary Identifier | MGI:1916366 | Organism | mouse, laboratory |
Chromosome | 4 | NCBI Gene Number | 69116 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in negative regulation of fatty acid biosynthetic process and ubiquitin-dependent protein catabolic process. Predicted to be located in several cellular components, including cytoplasm; cytoskeleton; and nucleus. Predicted to be active in centrosome; cytosol; and nucleoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human UBR4 (ubiquitin protein ligase E3 component n-recognin 4). PHENOTYPE: Mice homozygous for a transgenic gene disruption exhibit neonatal lethality and decreased body size at birth. Mice homozygous for a null mutation display complete embryonic lethality during organogenesis with arrest of vitelline vascular remodeling. [provided by MGI curators] |