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Protein Coding Gene : Krt12 keratin 12
Primary Identifier  MGI:96687 Organism  mouse, laboratory
Chromosome  11 NCBI Gene Number  268482
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Predicted to enable structural molecule activity. Involved in cornea development in camera-type eye and morphogenesis of an epithelium. Acts upstream of or within epithelium development. Predicted to be located in intermediate filament. Predicted to be active in cytoskeleton. Is expressed in cornea; cornea epithelium; head; lower jaw molar; and upper jaw molar. Used to study Meesmann corneal dystrophy. Human ortholog(s) of this gene implicated in Meesmann corneal dystrophy 1 and corneal dystrophy. Orthologous to human KRT12 (keratin 12).
PHENOTYPE: Homozygous null mutants display abnormal and fragile corneal epithelium. [provided by MGI curators]
  • synonyms:
  • expressed sequence AI835216,
  • MGI:2144270,
  • AI835216,
  • Krt1-12,
  • keratin complex 1, acidic, gene 12,
  • K12,
  • MGD-MRK-11642,
  • keratin 12,
  • Krt12
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Features --> Cross References

Genome

Sequence Feature Displayer

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0 CDSs

0 Exons

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2 Involved In Mutations

Trail: ProteinCodingGene

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0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

3 Pathways

Trail: ProteinCodingGene

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

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2 Driver For

Trail: ProteinCodingGene




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