| First Author | Fung-Leung WP | Year | 1991 |
| Journal | Cell | Volume | 65 |
| Issue | 3 | Pages | 443-9 |
| PubMed ID | 1673361 | Mgi Jnum | J:68956 |
| Mgi Id | MGI:1933767 | Doi | 10.1016/0092-8674(91)90462-8 |
| Citation | Fung-Leung WP, et al. (1991) CD8 is needed for development of cytotoxic T cells but not helper T cells. Cell 65(3):443-9 |
| abstractText | A mutant mouse strain without CD8 (Lyt-2 and Lyt-3) expression on the cell surface has been generated by disrupting the Lyt-2 gene using embryonic stem cell technology. In these mice, CD8+ T lymphocytes are not present in peripheral lymphoid organs, but the CD4+ T lymphocyte population seems to be unaltered. Cytotoxic response of T lymphocytes from these mice against alloantigens and viral antigens is dramatically decreased. Proliferative response against alloantigens and in vivo help to B lymphocytes, however, are not affected. These data suggest that CD8 is necessary for the maturation and positive selection of class I MHC restricted cytotoxic T lymphocytes but is not required on any of the intermediate thymocyte populations (CD8+CD4-TcR- or CD4+CD8+TcRlow) during the development of functional class II MHC restricted helper T cells. |
