| Primary Identifier | MGI:104641 | Organism | mouse, laboratory |
| Chromosome | 3 | NCBI Gene Number | 19288 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables (1->3)-beta-D-glucan binding activity. Acts upstream of or within several processes, including opsonization; ovarian cumulus expansion; and positive regulation of nitric oxide biosynthetic process. Located in extracellular matrix. Is expressed in dentate gyrus subgranular zone and inner ear. Human ortholog(s) of this gene implicated in cystic fibrosis and invasive aspergillosis. Orthologous to human PTX3 (pentraxin 3). PHENOTYPE: Homozygous mutant mice display female subfertility due to abnormalities of the cumulus oophorus and are susceptible to invasive pulmonary aspergillosis associated with defective recognition of conidia by alveolar macrophages and dendritic cells and impaired induction of adaptive type 2 responses. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
