| Primary Identifier | MGI:97359 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 18119 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables receptor ligand activity. Involved in several processes, including determination of left/right asymmetry in lateral mesoderm; nodal signaling pathway; and positive regulation of angiogenesis. Acts upstream of or within several processes, including axis specification; embryonic morphogenesis; and regulation of embryonic development. Located in extracellular region. Is expressed in several structures, including ectoderm; egg cylinder; embryo mesoderm; gonad; and primitive streak. Human ortholog(s) of this gene implicated in visceral heterotaxy. Orthologous to human NODAL (nodal growth differentiation factor). PHENOTYPE: Homozygous null mutants fail to form a primitive streak, show placental defects and die at gastrulation. Hypomorphic mutants are defective in anterior-posterior, anterior-midline, and left-right body patterning, resulting in multiple organ defects. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
