| First Author | Stocker AM | Year | 2006 |
| Journal | Brain Res | Volume | 1073-1074 |
| Pages | 151-8 | PubMed ID | 16457793 |
| Mgi Jnum | J:106946 | Mgi Id | MGI:3619804 |
| Doi | 10.1016/j.brainres.2005.12.057 | Citation | Stocker AM, et al. (2006) Differential expression of alpha-E-catenin and alpha-N-catenin in the developing cerebral cortex. Brain Res 1073-1074:151-8 |
| abstractText | Alpha (alpha) catenin proteins can regulate both cell adhesion and cell proliferation. Here, we characterize the expression of two forms of alpha-catenin, alphaE-catenin and alphaN-catenin, in the developing cerebral cortex and primary cortical cultures. In situ hybridization and immunofluorescence studies reveal that alphaE-catenin is highly expressed in neuroepithelial precursor cells in the developing cortical ventricular zone, with markedly reduced expression in the cortical plate; in contrast, alphaN-catenin expression is low in the ventricular zone and high in the developing cortical plate. In the ventricular zone, immunoreactivity for both alphaE-catenin and alphaN-catenin is enriched in rings at the lumenal surface, reflecting localization at adherens junctions together with beta-catenin. Expression of alphaE-catenin in primary cortical precursor cultures is initially robust, but declines as neural precursors differentiate into neurons. Reflecting its expression pattern in vivo, alphaN-catenin is expressed in both neural precursors as well in neurons differentiated in culture. These differential expression patterns of alphaE-catenin and alphaN-catenin suggest both distinct and overlapping functions during cortical development. |
