| First Author | Hughes AL | Year | 1999 |
| Journal | Immunogenetics | Volume | 49 |
| Issue | 2 | Pages | 115-24 |
| PubMed ID | 9887348 | Mgi Jnum | J:52233 |
| Mgi Id | MGI:1328666 | Doi | 10.1007/s002510050470 |
| Citation | Hughes AL, et al. (1999) Coevolution of the mammalian chemokines and their receptors. Immunogenetics 49(2):115-24 |
| abstractText | A phylogeny of mammalian chemokines revealed two major clusters, corresponding to the CC and CXC chemokines; the C chemokines appeared to be more closely related to the former. In a phylogeny of chemokine receptors, there were also two major clusters: one containing CC chemokine receptors plus other receptors of unknown function and another containing CXC receptors and other receptors of unknown function. However, within the CC receptors, there was not a close correspondence between the phylogenies of chemokines and their receptors. The CC chemokines contained two major subfamilies: (1) the MIP subfamily (including MIP-1alpha, MIP-1beta, and RANTES); and (2) the MCP subfamily (including MCP-1,-2,-3, and -4 and eotaxin). Receptors having preferred ligands in the MCP subfamily did not constitute a monophyletic group but rather evolved twice independently. Reconstruction of ancestral amino acid sequences suggested that these two groups of MCP receptors did not convergently evolve any amino acid residues; rather, they convergently lost sequence features found in the third and fourth extracellular domains of known receptors for MIP-subfamily chemokines. |
