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Allele : Mitf<Mi-wh> melanogenesis associated transcription factor; white

Primary Identifier  MGI:1856088 Allele Type  Spontaneous
Gene  Mitf Inheritance Mode  Semidominant
Strain of Origin  (C57BL x DBA)F1 Is Recombinase  false
Is Wild Type  false
description  Combination heterozygotes of MitfMi-wh/MitfMi, MitfMi-wh/MitfMi-b, and MitfMi-wh/MitfMi-ws show some interallelic complementation in that the heterozygote of the two alleles is more nearly normal than either homozygote (J:12967, J:19656). MitfMi-b/MitfMi-wh agouti mice are light cream with white spots and ruby eyes (J:15061).
molecularNote  T-to-A transversion at bp 764, which leads to an isoleucine to asparagine substitution at amino acid 212 in the encoded protein (p.I212N). This mutation is in the basic region of the protein.
  • mutations:
  • Single point mutation
  • synonyms:
  • Mi<wh>,
  • mitf<wh>,
  • mitf<wh>,
  • Mi<wh>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

20 Carried By

Trail: Allele

0 Driven By

42 Publication categories

Trail: Allele