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Protein Coding Gene : Ltbp1 latent transforming growth factor beta binding protein 1

Primary Identifier  MGI:109151 Organism  mouse, laboratory
Chromosome  17 NCBI Gene Number  268977
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0)

Predicted to enable microfibril binding activity; molecular adaptor activity; and transforming growth factor beta binding activity. Acts upstream of or within aorta development; coronary vasculature development; and ventricular septum development. Located in microfibril. Is expressed in several structures, including embryo mesenchyme; forebrain; genitourinary system; heart; and integumental system. Human ortholog(s) of this gene implicated in cutis laxa. Orthologous to human LTBP1 (latent transforming growth factor beta binding protein 1).
PHENOTYPE: Mice homozygous for a null allele exhibit embryonic and neonatal lethality associated with defects in the aortic arch and outflow tract. [provided by MGI curators]
  • synonyms:
  • MGI:1924572,
  • MGD-MRK-38195,
  • latent transforming growth factor beta binding protein 1,
  • Ltbp1L,
  • RIKEN cDNA 9430031G15 gene,
  • MGI:5316769,
  • b2b1000Clo,
  • 9430031G15Rik,
  • Ltbp1,
  • Mutant line 1000,
  • LTBP-1

Features --> Cross References

Genome

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0 CDSs

0 Exons

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0 Involved In Mutations

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0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

11 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

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0 Driver For