| First Author | Hou Y | Year | 2015 |
| Journal | Nat Immunol | Volume | 16 |
| Issue | 8 | Pages | 810-8 |
| PubMed ID | 26147687 | Mgi Jnum | J:233056 |
| Mgi Id | MGI:5780654 | Doi | 10.1038/ni.3204 |
| Citation | Hou Y, et al. (2015) The transcription factor Foxm1 is essential for the quiescence and maintenance of hematopoietic stem cells. Nat Immunol 16(8):810-8 |
| abstractText | Foxm1 is known as a typical proliferation-associated transcription factor. Here we found that Foxm1 was essential for maintenance of the quiescence and self-renewal capacity of hematopoietic stem cells (HSCs) in vivo in mice. Reducing expression of FOXM1 also decreased the quiescence of human CD34(+) HSCs and progenitor cells, and its downregulation was associated with a subset of myelodysplastic syndrome (MDS). Mechanistically, Foxm1 directly bound to the promoter region of the gene encoding the receptor Nurr1 (Nr4a2; called 'Nurr1' here), inducing transcription, while forced expression of Nurr1 reversed the loss of quiescence observed in Foxm1-deficient cells in vivo. Thus, our studies reveal a previously unrecognized role for Foxm1 as a critical regulator of the quiescence and self-renewal of HSCs mediated at least in part by control of Nurr1 expression. |
