| First Author | So EY | Year | 2013 |
| Journal | J Cancer Biol Res | Volume | 1 |
| Issue | 1 | PubMed ID | 25657994 |
| Mgi Jnum | J:222671 | Mgi Id | MGI:5645197 |
| Citation | So EY, et al. (2013) The Potential Role of BRCA1-Associated ATM Activator-1 (BRAT1) in Regulation of mTOR. J Cancer Biol Res 1(1) |
| abstractText | BRCA1-associated ATM activator-1 (BRAT1) was identified by our group as a DNA damage response (DDR) protein, which can bind with many DDR proteins and regulates their functions after DNA damage. However, previous study has also implicated BRAT1 as a regulator of cell growth and apoptosis. In this study, targeted gene deletion showed that BRAT1 is critical in stability and serum-induced expression of mTOR and downstream protein. Conditional deletion of BRAT1 of mouse embryonic fibroblasts suppressed serum-induced cell cycling progress. Our results suggest that BRAT1 is essential factor for PIKK signaling cascades. |
