| Primary Identifier | IPR029601 | Type | Family |
| Short Name | TRPM7 |
| description | The TRPM subfamily of mammalian TRP channels includes TRPM7, which is a bifunctional molecule consisting of a TRP ion channel fused to a serine/threonine-protein kinase domain. It conducts Zn(2+), Mg(2+), and Ca(2+) as well as monovalent cations []. The kinase domain is proteolytically cleaved from the channel domain in a cell-type-specific manner, with the cleaved kinase fragments translocating to the nucleus and binding multiple components of chromatin-remodeling complexes []. TRPM7 plays a prominent role in cellular and systemic magnesium homeostasis, and is a key player in embryonic development, global ischemia, cardiovascular disease, and cancer []. |
