| First Author | Binz C | Year | 2021 |
| Journal | Eur J Immunol | Volume | 51 |
| Issue | 11 | Pages | 2618-2632 |
| PubMed ID | 34398456 | Mgi Jnum | J:325587 |
| Mgi Id | MGI:7262818 | Doi | 10.1002/eji.202149243 |
| Citation | Binz C, et al. (2021) alphabeta T cells replacing dermal and epidermal gammadelta T cells in Tcrd(-/-) mice express an MHC-independent TCR repertoire. Eur J Immunol 51(11):2618-2632 |
| abstractText | The epidermis of mouse skin is usually populated by dendritic epidermal T cells (gammadeltaDETC) expressing an invariant Vgamma5Vdelta1(+) TCR. In Tcrd(-/-) mice, skin-resident gammadeltaDETC are replaced by alphabetaDETC carrying polyclonal alphabeta TCRs. Although they exhibit a dendritic morphology, alphabetaDETC were reported to be less functional than genuine gammadeltaDETC, likely because their TCR is unable to interact with the original TCR ligands of gammadeltaDETC. However, the TCR repertoire of those replacement DETC in Tcrd(-/-) mice might provide clues for understanding the development and selection of canonical gammadeltaDETC. Here, we compare the phenotype and TCR repertoires of wild-type and Tcrd(-/-) mouse skin T cells. Our data reveal that alphabetaDETC are CD4/CD8 double negative and express an MHC-independent TCR repertoire. Furthermore, we identify a second MHC-independent population of CD103(hi) CD4/ CD8 double-negative alphabeta T cells in the dermis of Tcrd(-/-) mice. |
