Primary Identifier | MGI:106244 | Organism | mouse, laboratory |
Chromosome | X | NCBI Gene Number | 52808 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable chromatin binding activity and histone binding activity. Predicted to be involved in negative regulation of DNA replication and negative regulation of cell growth. Predicted to act upstream of or within chromatin organization. Predicted to be located in nucleolus. Predicted to be part of chromatin. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Orthologous to human TSPYL2 (TSPY like 2). PHENOTYPE: Mice homozygous or hemizygous for a targeted allele are viable, fertile and do not exhibit increased tumor incidence; however, mutant mouse embryonic fibroblasts are impaired in cell cycle arrest following DNA damage induced by ionizing radiation. [provided by MGI curators] |