| Primary Identifier | MGI:96683 | Organism | mouse, laboratory |
| Chromosome | 5 | NCBI Gene Number | 16542 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables coreceptor activity; growth factor binding activity; and vascular endothelial growth factor receptor activity. Involved in several processes, including circulatory system development; positive regulation of BMP signaling pathway; and positive regulation of vasculogenesis. Acts upstream of or within several processes, including positive regulation of cell population proliferation; post-embryonic camera-type eye morphogenesis; and vasculature development. Located in several cellular components, including cell junction; endosome; and external side of plasma membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; extraembryonic component; and genitourinary system. Human ortholog(s) of this gene implicated in several diseases, including adhesions of uterus; artery disease (multiple); gastrointestinal system cancer (multiple); macular degeneration (multiple); and pancreatic cancer (multiple). Orthologous to human KDR (kinase insert domain receptor). PHENOTYPE: Homozygous mice die at early embryonic stages due to failure of blood vessel formation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
