| First Author | Lacey M | Year | 1986 |
| Journal | Nature | Volume | 322 |
| Issue | 6080 | Pages | 609-12 |
| PubMed ID | 3018579 | Mgi Jnum | J:102052 |
| Mgi Id | MGI:3606540 | Doi | 10.1038/322609a0 |
| Citation | Lacey M, et al. (1986) Bovine papillomavirus genome elicits skin tumours in transgenic mice. Nature 322(6080):609-12 |
| abstractText | Transmission of the bovine papillomavirus-1 (BPV-1) genome through the mouse germ line results in the heritable formation of fibropapillomas of the skin, a tissue-specific phenotype analogous to that observed in natural BPV-1 infection of cattle. Oncogenesis is slow, with tumours first arising at 8-9 months of age, usually in areas prone to wounding. Extrachromosomal BPV-1 DNA is detected in all tumours, whereas normal tissues show only integrated DNA. |
