| First Author | Engel P | Year | 2003 |
| Journal | Nat Rev Immunol | Volume | 3 |
| Issue | 10 | Pages | 813-21 |
| PubMed ID | 14523387 | Mgi Jnum | J:86136 |
| Mgi Id | MGI:2678860 | Doi | 10.1038/nri1202 |
| Citation | Engel P, et al. (2003) The SAP and SLAM families in immune responses and X-linked lymphoproliferative disease. Nat Rev Immunol 3(10):813-21 |
| abstractText | SAP (signalling lymphocytic activation molecule (SLAM)-associated protein) is a T- and natural killer (NK)-cell-specific protein containing a single SH2 domain encoded by a gene that is defective or absent in patients with X-linked lymphoproliferative syndrome (XLP). The SH2 domain of SAP binds with high affinity to the cytoplasmic tail of the haematopoietic cell-surface glycoprotein SLAM and five related receptors. SAP regulates signal transduction of the SLAM-family receptors by recruiting SRC kinases. Similarly, the SAP-related proteins EAT2A and EAT2B are thought to control signal transduction that is initiated by SLAM-related receptors in professional antigen-presenting cells. In this review, we discuss recent findings on the structure and function of proteins of the SAP and SLAM families. |
