| Primary Identifier | MGI:1349183 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 18829 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables CCR7 chemokine receptor binding activity and chemokine activity. Involved in several processes, including dendritic cell dendrite assembly; negative regulation of dendritic cell dendrite assembly; and positive regulation of T cell chemotaxis. Acts upstream of or within induction of positive chemotaxis and lymph node development. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in branchial arch; hemolymphoid system; renal vasculature; and trunk. Orthologous to human CCL21 (C-C motif chemokine ligand 21). PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired negative T cell selection with small thymus medulla, decreased thymic B cells and autoimmune dacryoadenitis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
