| Primary Identifier | MGI:6120542 | Allele Type | Endonuclease-mediated |
| Gene | Mfsd2a | Strain of Origin | (C57BL/6J x SJL/J)F1/J |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | An A to C mutation resulting in a D96A substitution was inserted in exon 3 by CRISPR/Cas9 mediated recombination. Immunohistochemical and western blot analysis indicated no change in protein expression in the brains of homozygous mice compared to wild-type controls. Altered lipid profiles in the brains of homozygotes indicate this mutation abolishes the lipid transport function of the gene. |
