Primary Identifier | MGI:4365828 | Allele Type | Targeted |
Gene | Otx2 | Transmission | Germline |
Strain of Origin | 129P2/OlaHsd | Is Recombinase | false |
Is Wild Type | false |
molecularNote | The major and two cryptic splice sites upstream from the translation initiation codon were mutagenized and a floxed neo cassette was inserted into the downstream intron. The absence of protein expression of isoforms A and B was confirmed by western blot analysis. Expression of isoforms C and D are normal. |