| First Author | Inoue J | Year | 1999 |
| Journal | Biosci Biotechnol Biochem | Volume | 63 |
| Issue | 1 | Pages | 243-5 |
| PubMed ID | 10052151 | Mgi Jnum | J:53660 |
| Mgi Id | MGI:1333260 | Doi | 10.1271/bbb.63.243 |
| Citation | Inoue J, et al. (1999) A novel splicing isoform of mouse sterol regulatory element-binding protein-1 (SREBP-1). Biosci Biotechnol Biochem 63(1):243-5 |
| abstractText | We cloned a cDNA encoding the NH2-terminal portion of mouse SREBP-1. The deduced amino acid sequence was 76% and 90% identical to human and hamster SREBP-1, respectively. We found out a novel splicing isoform of mouse SREBP-1 that lacks 42 amino acid residues composing a PEST sequence observed in unstable proteins. It has been reported that SREBP-1 is rapidly turned over in the nucleus. Although this isoform was not a dominant isoform, it might be possible that the produced protein functions differently from other isoforms including a complete PEST sequence. |
