| First Author | Wainwright BJ | Year | 1988 |
| Journal | EMBO J | Volume | 7 |
| Issue | 6 | Pages | 1743-8 |
| PubMed ID | 2971536 | Mgi Jnum | J:9380 |
| Mgi Id | MGI:57841 | Doi | 10.1002/j.1460-2075.1988.tb03003.x |
| Citation | Wainwright BJ, et al. (1988) Isolation of a human gene with protein sequence similarity to human and murine int-1 and the Drosophila segment polarity mutant wingless. EMBO J 7(6):1743-8 |
| abstractText | An expressed gene sequence which was identified by the isolation of a methylation free CpG island from human chromosome 7 has been cloned from a human lung cDNA library. The deduced protein sequence contains 360 amino acids and has several features of a secreted protein; it is cysteine rich with a signal peptide sequence and two potential asn-linked glycosylation sites. The protein sequence shows marked similarity with human and murine int-1 and their Drosophila homolog wingless (Dint-1). This human int-1 related protein, int-1 and Dint-1 have diverse patterns of expression, but the inferred structural similarities suggest that some of the functional characteristics of these proteins may be shared. |
