| Primary Identifier | IPR033988 | Type | Domain |
| Short Name | CEL1-like_CTLD |
| description | This entry represents the C-type lectin-like domain (CTLD) of the type found in CEL-1 from Cucumaria echinata, and Echinoidin from Anthocidaris crassispina amongst others. CTLD refers to a domain homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins []. The CEL-1 CTLD binds three calcium ions and has a high specificity for N-acteylgalactosamine (GalNAc) [, ]. CEL-1 exhibits strong cytotoxicity which is inhibited by GalNAc []. This protein may play a role as a toxin defending against predation. Echinoidin is found in the coelomic fluid of the sea urchin and is specific for GalBeta1-3GalNAc []. Echinoidin has a cell adhesive activity towards human cancer cells which is not mediated through the CTLD []. Both CEL-1 and Echinoidin are multimeric proteins comprised of multiple dimers linked by disulfide bonds. |
