| First Author | Klocke R | Year | 1997 |
| Journal | Genomics | Volume | 41 |
| Issue | 2 | Pages | 290-2 |
| PubMed ID | 9143510 | Mgi Jnum | J:39830 |
| Mgi Id | MGI:87179 | Doi | 10.1006/geno.1997.4634 |
| Citation | Klocke R, et al. (1997) Dynamin genes Dnm1 and Dnm2 are located on proximal mouse chromosomes 2 and 9, respectively. Genomics 41(2):290-2 |
| abstractText | Dynamins, microtubule-binding GTPases, are encoded by at least three genes in mammals. Two distinct gene-specific cDNAs were used to analyze the segregation of dynamin genes Dnm1 and Dnm2 in a mouse interspecies backcross. The nervous system expressed gene Dnm1 was localized to Chr 2 between the genes for vimentin and nebulin, within a chromosomal region of conserved synteny to human chromosome 9q, consistent with the localization of the human dynamin-1 gene by FISH (see accompanying paper by Newman-Smith et al., 1997, Genomics 41: 286-289). The ubiquitously expressed Dnm2 gene was found to be closely linked to the intercellular adhesion molecule-1 gene, Icam1, in a region with homologies to human chromosomes 19p, 8q, and 11q. Potential relations of both loci to disease genes are discussed. (C) 1997 Academic Press. |
