| First Author | Liu J | Year | 2001 |
| Journal | Immunity | Volume | 15 |
| Issue | 1 | Pages | 23-34 |
| PubMed ID | 11485735 | Mgi Jnum | J:70594 |
| Mgi Id | MGI:2137821 | Doi | 10.1016/s1074-7613(01)00162-5 |
| Citation | Liu J, et al. (2001) Enhanced CD4+ T cell proliferation and Th2 cytokine production in DR6-deficient mice. Immunity 15(1):23-34 |
| abstractText | We have found that DR6, a member of the TNF receptor family, is highly expressed in resting T cells and downregulated in activated T cells. DR6-targeted mutant mice were generated and showed normal development. However, DR6(-/-) CD4(+) T cells hyperproliferated in response to TCR-mediated stimulation and protein antigen challenge. Activated DR6(-/-) CD4(+) T cells exhibited upregulated CD25 expression and enhanced proliferation in response to exogenous IL-2 stimulation. In addition, increased CD28 and reduced CTLA-4 expression were observed in these cells. Enhanced Th2 cytokine production by activated DR6(-/-) CD4(+) T cells was associated with the increased transcription factor NF-ATc in nuclei. DR6, therefore, functions as a regulatory receptor for mediating CD4(+) T cell activation and maintaining proper immune responses. |
