| Primary Identifier | IPR046383 | Type | Family |
| Short Name | Phage_PurZ |
| description | This family includes N6-succino-2-amino-2'-deoxyadenylate synthase PurZ from phages. It is involved in the synthesis of the atypical nucleotide dZTP (2-amino-2'-deoxyadenosine-5'-triphosphate) and in the synthesis of N6-succino-2-amino-2'-deoxyadenylate, which undergoes defumarylation and phosphorylation respectively by host PurB and guanylate/nucleoside diphosphate kinases to give dZTP (2-amino-2'-deoxyadenosine-5'-triphosphate). dZTP is integrated into the viral genome instead of adenine by the viral polymerase. This Z-base probably completely replaces adenosine and forms a triple bond to the opposite T-base. The resulting non-standard viral DNA is called Z-genome. The chemically modified DNA is probably harder for the host bacteria to digest with nucleases or restriction enzymes [, ]. |
