| First Author | Cheng Y | Year | 1994 |
| Journal | Biochim Biophys Acta | Volume | 1217 |
| Issue | 3 | Pages | 307-11 |
| PubMed ID | 8148376 | Mgi Jnum | J:17596 |
| Mgi Id | MGI:65630 | Doi | 10.1016/0167-4781(94)90290-9 |
| Citation | Cheng Y, et al. (1994) Organization of the mouse GP42/Basigin gene: a member of the Ig superfamily. Biochim Biophys Acta 1217(3):307-11 |
| abstractText | We have mapped and sequenced the GP42/Basigin gene isolated from a Balb/C mouse genomic library. The genomic organization and upstream, putative regulatory, regions of this gene have not been previously reported. Our data show that exon 5 of the GP42/Basigin gene encodes the carboxy proximal half of the second Ig-like domain, the highly conserved transmembrane region and a portion of the cytoplasmic tail. This inclusion of Ig-like and other functional domains in a single exon is unusual. Splice junction analysis indicates that two reported alternate GP42/Basigin cDNA isoforms are likely due to cloning artifacts. In addition, we find that GP42/Basigin is polymorphic in mice. Our data also support the proposal that the transmembrane domain and portions of the cytoplasmic region of GP42/Basigin have been evolutionarily conserved. |
