| First Author | Duca FA | Year | 2015 |
| Journal | Cell Metab | Volume | 22 |
| Issue | 3 | Pages | 367-80 |
| PubMed ID | 26212718 | Mgi Jnum | J:228096 |
| Mgi Id | MGI:5705204 | Doi | 10.1016/j.cmet.2015.07.003 |
| Citation | Duca FA, et al. (2015) Glucoregulatory Relevance of Small Intestinal Nutrient Sensing in Physiology, Bariatric Surgery, and Pharmacology. Cell Metab 22(3):367-80 |
| abstractText | Emerging evidence suggests the gastrointestinal tract plays an important glucoregulatory role. In this perspective, we first review how the intestine senses ingested nutrients, initiating crucial negative feedback mechanisms through a gut-brain neuronal axis to regulate glycemia, mainly via reduction in hepatic glucose production. We then highlight how intestinal energy sensory mechanisms are responsible for the glucose-lowering effects of bariatric surgery, specifically duodenal-jejunal bypass, and the antidiabetic agents metformin and resveratrol. A better understanding of these pathways lays the groundwork for intestinally targeted drug therapy for the treatment of diabetes. |
