| First Author | Costalonga M | Year | 2007 |
| Journal | Immunology | Volume | 122 |
| Issue | 1 | Pages | 124-30 |
| PubMed ID | 17484770 | Mgi Jnum | J:125617 |
| Mgi Id | MGI:3759332 | Doi | 10.1111/j.1365-2567.2007.02620.x |
| Citation | Costalonga M, et al. (2007) Lipopolysaccharide enhances in vivo interleukin-2 production and proliferation by naive antigen-specific CD4 T cells via a Toll-like receptor 4-dependent mechanism. Immunology 122(1):124-30 |
| abstractText | Microbial adjuvants are essential for the development of T-cell-dependent antibody production, recall T-cell proliferation and interferon-gamma production following immunization with protein antigens. Using an adoptive transfer approach, we showed that the adjuvant lipopolysaccharide enhanced the frequency of cells producing interleukin-2, enhanced clonal expansion by antigen-specific CD4 T cells and increased CD86 and interleukin-1alpha production by antigen-presenting cells. All of these effects were dependent on Toll-like receptor-4 (TLR4) expression by cells other than the antigen-specific CD4 T cells. The ability of lipopolysaccharides to increase the number of antigen-specific CD4 T cells that survive after immunization probably explains the previous finding that antigen-specific proliferation by T cells from normal mice depends on previous exposure to antigen and adjuvant. |
