| Primary Identifier | MGI:109587 | Organism | mouse, laboratory |
| Chromosome | 15 | NCBI Gene Number | 18383 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables heparan sulfate binding activity. Involved in negative regulation of osteoclast differentiation. Acts upstream of or within extracellular matrix organization; negative regulation of odontogenesis of dentin-containing tooth; and negative regulation of tumor necrosis factor-mediated signaling pathway. Located in extracellular matrix. Is expressed in several structures, including arterial system; bone; gut; hemolymphoid system gland; and placenta. Used to study osteoporosis. Human ortholog(s) of this gene implicated in Paget's disease of bone; Paget's disease of bone 5; and osteoarthritis. Orthologous to human TNFRSF11B (TNF receptor superfamily member 11b). PHENOTYPE: Homozygote null mice have abnormal bone remodeling that results in severe osteoperosis with increased risk of fractures and growth retardation. Progressive hearing loss also results due to abnormal remodeling of the otic capsule. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
