| First Author | Umeda T | Year | 2000 |
| Journal | Int J Oncol | Volume | 16 |
| Issue | 6 | Pages | 1133-6 |
| PubMed ID | 10811985 | Mgi Jnum | J:78280 |
| Mgi Id | MGI:2183889 | Doi | 10.3892/ijo.16.6.1133 |
| Citation | Umeda T, et al. (2000) beta-catenin mutations are absent in hepatocellular carcinomas of SV40 T-antigen transgenic mice. Int J Oncol 16(6):1133-6 |
| abstractText | beta-catenin mutations have been found not only in melanoma and prostatic carcinoma but also in hepatocellular carcinomas in human, c-myc, H-ras genes transgenic mice and chemically-induced models. We investigated beta-catenin mutations in human hepatocellular carcinomas (HCCs), Hep G2 cell line and HCCs in SV40 T-antigen transgenic mice, in order to examine whether beta-catenin mutations are frequently observed in HCC in general. We found a point mutation of beta-catenin in one of nine HCCs in human and a deletion of it in Hep G2 cell line. However, we found no mutation in HCC in SV40 TG mice liver. |
