| Primary Identifier | MGI:96160 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 15361 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables several functions, including DNA binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and transcription coactivator activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including hemopoiesis; peroxisome proliferator activated receptor signaling pathway; and response to peptide hormone. Located in male germ cell nucleus. Part of RNA polymerase II transcription regulator complex and SUMO ligase complex. Is active in mitochondrion and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human HMGA1 (high mobility group AT-hook 1). PHENOTYPE: Although haploinsufficiency at this locus is not compatible with germline transmission of one allele at this locus, mice homozygous for two other disruptions are fertile. Abnormalities are seen in glucose metabolism and in the cardiovascular system. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
