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Protein Coding Gene : Gfra4 glial cell line derived neurotrophic factor family receptor alpha 4
Primary Identifier  MGI:1341873 Organism  mouse, laboratory
Chromosome  2 NCBI Gene Number  14588
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Predicted to enable glial cell-derived neurotrophic factor receptor activity. Acts upstream of or within negative regulation of ossification. Predicted to be located in extracellular space. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including brain; endocrine gland; ganglia; spinal cord; and testis. Orthologous to human GFRA4 (GDNF family receptor alpha 4).
PHENOTYPE: Homozygotes for targeted null mutations are mice were viable, fertile, showed no overt anatomical defects. Thyroid tissue calcitonin content was reduced in null homozygotes and rate of bone formation was enhanced when in 129/B6 hybrid background strain. [provided by MGI curators]
  • synonyms:
  • GFR alpha-4,
  • MGI:2139291,
  • Gfra4,
  • RIKEN cDNA G630015H18 gene,
  • AW060733,
  • glial cell line derived neurotrophic factor family receptor alpha 4,
  • expressed sequence AW060733,
  • G630015H18Rik
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Features --> Cross References

Genome

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0 Canonical

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2 Involved In Mutations

Trail: ProteinCodingGene

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0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

8 Pathways

Trail: ProteinCodingGene

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Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

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