| Primary Identifier | MGI:1924833 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 77583 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables lipase activity and palmitoleyl hydrolase activity. Involved in negative regulation of Wnt signaling pathway. Acts upstream of or within bone development; negative regulation of canonical Wnt signaling pathway; and regulation of bone mineralization. Predicted to be located in extracellular region. Is expressed in several structures, including alimentary system; genitourinary system; primitive streak; respiratory system; and sensory organ. Orthologous to human NOTUM (notum, palmitoleoyl-protein carboxylesterase). PHENOTYPE: Mice homozygous for a null mutation display perinatal lethality, abnormal kidney development, and impaired tracheal cartilage development. Mice homozygous for a gene trapped allele exhibit abnormal dentin development, periodontal inflammation, tooth decay and increased bone mineral density. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
