| First Author | Kreslavsky T | Year | 2013 |
| Journal | J Exp Med | Volume | 210 |
| Issue | 10 | Pages | 1911-8 |
| PubMed ID | 23980099 | Mgi Jnum | J:202851 |
| Mgi Id | MGI:5522613 | Doi | 10.1084/jem.20130876 |
| Citation | Kreslavsky T, et al. (2013) Negative selection, not receptor editing, is a physiological response of autoreactive thymocytes. J Exp Med 210(10):1911-8 |
| abstractText | Antigen receptor editing-a process of secondary rearrangements of antigen receptor genes in autoreactive lymphocytes-is a well-established tolerance mechanism in B cells, whereas its role in T cells remains controversial. Here, we investigated this issue using a novel Tcra knock-in locus, which ensured appropriate timing of TCRalpha expression and allowed secondary rearrangements. Under these conditions the only response to self-antigen that could be unambiguously identified was negative selection of CD4/CD8 double positive thymocytes. No evidence could be obtained for antigen-induced TCR editing, whereas replacement of the transgenic TCRalpha chain by ongoing gene rearrangement occurred in some cells irrespective of the presence or absence of self-antigen. |
