| First Author | Adams MT | Year | 2023 |
| Journal | FASEB J | Volume | 37 |
| Issue | 8 | Pages | e23106 |
| PubMed ID | 37498234 | Mgi Jnum | J:346295 |
| Mgi Id | MGI:7614894 | Doi | 10.1096/fj.202200705RR |
| Citation | Adams MT, et al. (2023) Disrupted glucose homeostasis and glucagon and insulin secretion defects in Robo betaKO mice. FASEB J 37(8):e23106 |
| abstractText | The axon guidance proteins, Roundabout (Robo) receptors play a critical role in morphogenesis of the islets of Langerhans. Mice with a beta cell-selective deletion of Robo (Robo betaKO), show severely disrupted spatial architecture of their islets, without defects in beta cell differentiation or maturity. We have recently shown that Robo betaKO mice have reduced synchronous glucose-stimulated beta cell calcium oscillations in their islets in vivo, likely disrupting their pulsatile insulin secretion. Here, we analyze whole-body metabolic regulation in Robo betaKO mice. We show that Robo betaKO mice have mild defects in glucose homeostasis, and altered glucagon and insulin secretion. However, we did not observe any severe whole-body glucoregulatory phenotype following the disruption of islet architecture in Robo betaKO. Our data suggest that islet architecture plays only a mild role in overall glucoregulation. |
