| Primary Identifier | MGI:1934852 | Organism | mouse, laboratory |
| Chromosome | 14 | NCBI Gene Number | 93732 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity; anion binding activity; and palmitoyl-CoA oxidase activity. Predicted to be involved in lipid homeostasis and monocarboxylic acid metabolic process. Predicted to act upstream of or within fatty acid metabolic process. Predicted to be located in cytosol and intracellular membrane-bounded organelle. Predicted to be active in peroxisome. Is expressed in several structures, including heart ventricle; liver; metanephros; and trunk. Human ortholog(s) of this gene implicated in congenital bile acid synthesis defect 6. Orthologous to human ACOX2 (acyl-CoA oxidase 2). PHENOTYPE: About 29% of mice homozygous for an endonuclease-mediated deletion spontaneously develop liver cancer at 8-9 months and exhibit liver inflammation and bile duct proliferation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
