| Primary Identifier | MGI:3053860 | Allele Type | Targeted |
| Attribute String | Null/knockout, Reporter | Gene | Mal |
| Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A lacZ/neo cassette was inserted in frame after the third codon in exon 1, replacing the remainder of exon 1. Southern blot confirmed recombination in mutant mice. Northern blot indicated a lack of full-length transcript in homozygotes, but presence of a lacZ-containing transcript in homozygotes and heterozygotes. Absence of wild-type protein was demonstrated by an immunohistochemistry assay of sciatic nerves and brain from mutants. |
