| First Author | Shearman LP | Year | 1999 |
| Journal | Neuroreport | Volume | 10 |
| Issue | 3 | Pages | 613-8 |
| PubMed ID | 10208599 | Mgi Jnum | J:54424 |
| Mgi Id | MGI:1335277 | Doi | 10.1097/00001756-199902250-00031 |
| Citation | Shearman LP, et al. (1999) Photic induction of Period gene expression is reduced in Clock mutant mice. Neuroreport 10(3):613-8 |
| abstractText | THE Clock mutation leads to abnormal circadian behavior and defective transcriptional activity of CLOCK, a basic helix-loop-helix (bHLH)/PAS protein. In situ hybridization was used to assess whether the Clock mutation affects the photic induction of mPeu1, mPer2, and c-fos in the mouse suprachiasmatic nucleus (SCN). Exposure of wild-type mice to a 15 min light pulse at night rapidly induced expression of c-fos mRNA, with mPer1 and mPer2 mRNAs peaking later. Light exposure also increased c-fos, mPer1 and mPer2 mRNA levels in the SCN of homozygous Clock mutant mice, but the amplitude of the response to light was significantly reduced. Clock appears to play a role in circadian photoreception that is distinct from its role in the circadian oscillatory mechanism. (C) 1999 Lippincott Williams & Wilkins. |
