| First Author | Hintsch G | Year | 2002 |
| Journal | Mol Cell Neurosci | Volume | 21 |
| Issue | 3 | Pages | 393-409 |
| PubMed ID | 12498782 | Mgi Jnum | J:80943 |
| Mgi Id | MGI:2447551 | Doi | 10.1006/mcne.2002.1181 |
| Citation | Hintsch G, et al. (2002) The calsyntenins-a family of postsynaptic membrane proteins with distinct neuronal expression patterns. Mol Cell Neurosci 21(3):393-409 |
| abstractText | We have identified two novel postsynaptic membrane proteins that are highly similar to calsyntenin-1 in their extracellular parts but vary considerably in their cytoplasmic segment. Calsyntenin-1 has recently been identified in our lab as a postsynaptic membrane protein with a highly acidic cytoplasmic segment with putative Ca(2+)-binding capacity (Vogt et al., 2001, Mol. Cell. Neurosci. 17: 151-166). Based on their structural similarity to calsyntenin-1, we have called the novel proteins calsyntenin-2 and -3, respectively. By immunoelectron microscopy, the calsyntenin protein family was localized in the postsynaptic membrane of excitatory central nervous system (CNS) synapses. In situ hybridization analysis revealed that calsyntenin-1 was abundant in most neurons of the CNS with relatively little variation in its expression level. Calsyntenin-2 and -3 expressions varied much more with highest levels in GABAergic neurons. Based on their distinct expression patterns and the differences in their cytoplasmic segments, we suggest a cell-type-specific functional role for the three calsyntenins in excitatory synaptic transmission. Key Words: calsyntenin-1; calsyntenin-2; calsyntenin-3; calcium-binding protein; calcium signaling; synapse; synaptic protein; plasticity. |
