| First Author | Sakagami H | Year | 2014 |
| Journal | Brain Res | Volume | 1586 |
| Pages | 23-33 | PubMed ID | 25152467 |
| Mgi Jnum | J:215376 | Mgi Id | MGI:5605199 |
| Doi | 10.1016/j.brainres.2014.08.051 | Citation | Sakagami H, et al. (2014) Preferential localization of type I phosphatidylinositol 4-phosphate 5-kinase gamma at the periactive zone of mouse photoreceptor ribbon synapses. Brain Res 1586:23-33 |
| abstractText | Type I phosphatidylinositol 4-phosphate 5 kinase gamma (PIP5KIgamma) constitutes a major pathway for the generation of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) that regulates a variety of neuronal functions at both presynaptic and postsynaptic compartments. In this study, we examined the expression and localization of PIP5KIgamma in the adult mouse retina. RT-PCR analysis revealed that PIP5KIgamma_v2 was predominantly expressed in the retina while PIP5KIgamma_v3 was also expressed faintly. Immunostaining of the adult mouse retina revealed intense PIP5KIgamma-immunoreactivity in the inner and outer plexiform layers in a punctate manner. In the photoreceptor ribbon synapse, PIP5KIgamma was highly concentrated at the periactive zone. These findings suggest that PIP5KIgamma, especially PIP5KIgamma_i2, is localized at the periactive zone, a functionally suitable compartment for the endocytosis of synaptic vesicles in photoreceptor ribbon synapses. |
