| First Author | Leow CC | Year | 2009 |
| Journal | J Biol Chem | Volume | 284 |
| Issue | 31 | Pages | 21057-65 |
| PubMed ID | 19494112 | Mgi Jnum | J:153183 |
| Mgi Id | MGI:4361105 | Doi | 10.1074/jbc.M109.001776 |
| Citation | Leow CC, et al. (2009) Prostate-specific Klf6 inactivation impairs anterior prostate branching morphogenesis through increased activation of the Shh pathway. J Biol Chem 284(31):21057-65 |
| abstractText | Kruppel-like factor 6 (Klf6) belongs to a family of zinc finger transcription factors known to play a role in development and tumor suppression. Although Klf6 is highly mutated in prostate cancer, its function in prostate development is unknown. We have generated a prostate-specific Klf6-deficient mouse model and report here a novel role for Klf6 in the regulation of prostate branching morphogenesis. Importantly, our study reveals a novel relationship between Klf6 and the Shh pathway. Klf6-deficiency leads to elevated levels of hedgehog pathway components (Shh, Ptc, and Gli) and loss of their localized expression, which in turn causes impaired lateral branching. |
