First Author | Clemons KV | Year | 2004 |
Journal | Infect Immun | Volume | 72 |
Issue | 8 | Pages | 4878-80 |
PubMed ID | 15271952 | Mgi Jnum | J:107884 |
Mgi Id | MGI:3622449 | Doi | 10.1128/IAI.72.8.4878-4880.2004 |
Citation | Clemons KV, et al. (2004) Genetic susceptibility of mice to Candida albicans vaginitis correlates with host estrogen sensitivity. Infect Immun 72(8):4878-80 |
abstractText | We compared susceptibility to Candida vaginitis in derived murine substrains differing in sensitivity to estrogen (CD-1 and CD10, resistant; CD3 and C57BL/6 responsive), and in F1 crosses. The order of decreasing resistance was CD-1 > or = CD10 > or = CD10 x CD3F1 > CD10 x B6F1 > CD3 > C57BL/6 and correlated with estrogen responsiveness in endocrine disruptor assays. Resistance to Candida vaginitis appears additive in CD10 x B6F1 animals and dominant in CD10 x CD3F1 animals. |