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Publication : Genetic susceptibility of mice to Candida albicans vaginitis correlates with host estrogen sensitivity.

First Author  Clemons KV Year  2004
Journal  Infect Immun Volume  72
Issue  8 Pages  4878-80
PubMed ID  15271952 Mgi Jnum  J:107884
Mgi Id  MGI:3622449 Doi  10.1128/IAI.72.8.4878-4880.2004
Citation  Clemons KV, et al. (2004) Genetic susceptibility of mice to Candida albicans vaginitis correlates with host estrogen sensitivity. Infect Immun 72(8):4878-80
abstractText  We compared susceptibility to Candida vaginitis in derived murine substrains differing in sensitivity to estrogen (CD-1 and CD10, resistant; CD3 and C57BL/6 responsive), and in F1 crosses. The order of decreasing resistance was CD-1 > or = CD10 > or = CD10 x CD3F1 > CD10 x B6F1 > CD3 > C57BL/6 and correlated with estrogen responsiveness in endocrine disruptor assays. Resistance to Candida vaginitis appears additive in CD10 x B6F1 animals and dominant in CD10 x CD3F1 animals.
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