| First Author | Lee H | Year | 2010 |
| Journal | Biochem Biophys Res Commun | Volume | 398 |
| Issue | 4 | Pages | 741-6 |
| PubMed ID | 20627088 | Mgi Jnum | J:163933 |
| Mgi Id | MGI:4830205 | Doi | 10.1016/j.bbrc.2010.07.015 |
| Citation | Lee H, et al. (2010) Beta-Catenin mediates the anti-adipogenic effect of baicalin. Biochem Biophys Res Commun 398(4):741-6 |
| abstractText | beta-Catenin reportedly inhibits adipogenesis through the down-regulations of peroxisome proliferator-activated receptor (PPAR)gamma and CCAAT/enhancer binding protein (C/EBP)alpha. We report that baicalin, a natural flavonoid compound, inhibits adipogenesis by modulating beta-Catenin. During 3T3-L1 cell adipogenesis, beta-Catenin was down-regulated, but baicalin treatment maintained beta-Catenin expression. Anti-adipogenic effects of baicalin were significantly attenuated by beta-Catenin siRNA transfection. beta-Catenin siRNA rescued the reduced expressions of PPARgamma, C/EBPalpha, fatty acid binding protein 4 and lipoprotein lipase by baicalin. Furthermore, baicalin modulated members of the WNT/beta-Catenin pathway by maintaining the expressions of low-density lipoprotein receptor-related protein 6, disheveled (DVL)2 and DVL3. These findings suggest that beta-Catenin mediates the anti-adipogenic effects of baicalin. |
