| Primary Identifier | MGI:96600 | Organism | mouse, laboratory |
| Chromosome | 13 | NCBI Gene Number | 16398 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0) Enables amyloid-beta binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; positive regulation of cell migration; and positive regulation of cellular component organization. Located in basal part of cell and external side of plasma membrane. Is expressed in several structures, including alimentary system; cardiovascular system; eye; genitourinary system; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); blood platelet disease (multiple); diabetes mellitus (multiple); retinal vascular disease (multiple); and von Willebrand's disease (multiple). Orthologous to human ITGA2 (integrin subunit alpha 2). PHENOTYPE: Homozygotes for targeted null mutations were viable, fertile, showed no overt anatomical defects, and exhibited no bleeding anomalies. Platelet, primary fibroblast and keratinocytes from homozygous mutant mice show less efficient adhesion to collagens in vitro. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
