| First Author | Nagata Y | Year | 1992 |
| Journal | Experientia | Volume | 48 |
| Issue | 8 | Pages | 753-5 |
| PubMed ID | 1355447 | Mgi Jnum | J:2778 |
| Mgi Id | MGI:51300 | Doi | 10.1007/BF02124295 |
| Citation | Nagata Y (1992) Involvement of D-amino acid oxidase in elimination of D-serine in mouse brain. Experientia 48(8):753-5 |
| abstractText | The physiological role of D-amino acid oxidase (EC 1. 4. 3. 3) in mouse brain is described. The presence of D-enantiomers of neutral common amino acids was surveyed in the brain. D-serine was shown to be present at high concentration only in regions where the enzyme activity was low. In normal mice whose D-amino acid oxidase activity was much higher in the cerebellum than in the cerebrum, free D-serine content was apparently lower in the cerebellum than in the cerebrum. In mice of a mutant strain lacking D-amino acid-oxidase activity, the free D-serine level was remarkably high both in the cerebrum and cerebellum. The results suggest that the enzyme is involved in the elimination of free D-serine in the cerebellum. |
