| First Author | Tsuchida T | Year | 2010 |
| Journal | Immunity | Volume | 33 |
| Issue | 5 | Pages | 765-76 |
| PubMed ID | 21074459 | Mgi Jnum | J:166835 |
| Mgi Id | MGI:4849871 | Doi | 10.1016/j.immuni.2010.10.013 |
| Citation | Tsuchida T, et al. (2010) The ubiquitin ligase TRIM56 regulates innate immune responses to intracellular double-stranded DNA. Immunity 33(5):765-76 |
| abstractText | The innate immune system detects pathogen- and host-derived double-stranded DNA exposed to the cytosol and induces type I interferon (IFN) and other cytokines. Here, we identified interferon-inducible tripartite-motif (TRIM) 56 as a regulator of double-stranded DNA-mediated type I interferon induction. TRIM56 overexpression enhanced IFN-beta promoter activation after double-stranded DNA stimulation whereas TRIM56 knockdown abrogated it. TRIM56 interacted with STING and targeted it for lysine 63-linked ubiquitination. This modification induced STING dimerization, which was a prerequisite for recruitment of the antiviral kinase TBK1 and subsequent induction of IFN-beta. Taken together, these results indicate that TRIM56 is an interferon-inducible E3 ubiquitin ligase that modulates STING to confer double-stranded DNA-mediated innate immune responses. |
