| First Author | Toritsuka M | Year | 2017 |
| Journal | Transl Psychiatry | Volume | 7 |
| Issue | 3 | Pages | e1049 |
| PubMed ID | 28267151 | Mgi Jnum | J:277541 |
| Mgi Id | MGI:6296193 | Doi | 10.1038/tp.2017.21 |
| Citation | Toritsuka M, et al. (2017) Regulation of striatal dopamine responsiveness by Notch/RBP-J signaling. Transl Psychiatry 7(3):e1049 |
| abstractText | Dopamine signaling is essential for reward learning and fear-related learning, and thought to be involved in neuropsychiatric diseases. However, the molecular mechanisms underlying the regulation of dopamine responsiveness is unclear. Here we show the critical roles of Notch/RBP-J signaling in the regulation of dopamine responsiveness in the striatum. Notch/RBP-J signaling regulates various neural cell fate specification, and neuronal functions in the adult central nervous system. Conditional deletion of RBP-J specifically in neuronal cells causes enhanced response to apomorphine, a non-selective dopamine agonist, and SKF38393, a D1 agonist, and impaired dopamine-dependent instrumental avoidance learning, which is corrected by SCH23390, a D1 antagonist. RBP-J deficiency drastically reduced dopamine release in the striatum and caused a subtle decrease in the number of dopaminergic neurons. Lentivirus-mediated gene transfer experiments showed that RBP-J deficiency in the striatum was sufficient for these deficits. These findings demonstrated that Notch/RBP-J signaling regulates dopamine responsiveness in the striatum, which may explain the mechanism whereby Notch/RBP-J signaling affects an individual's susceptibility to neuropsychiatric disease. |
