| First Author | Ishimaru N | Year | 2006 |
| Journal | Nat Immunol | Volume | 7 |
| Issue | 7 | Pages | 763-72 |
| PubMed ID | 16732290 | Mgi Jnum | J:112642 |
| Mgi Id | MGI:3662961 | Doi | 10.1038/ni1351 |
| Citation | Ishimaru N, et al. (2006) Regulation of naive T cell function by the NF-kappaB2 pathway. Nat Immunol 7(7):763-72 |
| abstractText | T cell activation involves the orchestration of several signaling pathways, including that of the 'classical' transcription factor NF-kappaB components NF-kappaB1-RelA. The function of the 'nonclassical' NF-kappaB2-RelB pathway is less clear, although T cells lacking components of this pathway have activation defects. Here we show that mice deficient in NF-kappaB-inducing kinase have a complex phenotype consisting of immunosuppression mediated by CD25(-)Foxp3(-) memory CD4(+) cells and, in the absence of those cells, hyper-responsive naive CD4(+) T cells, which caused autoimmune lesions after adoptive transfer into hosts deficient in recombination-activating genes. Biochemical studies indicated involvement of a cell-intrinsic mechanism in which NF-kappaB2 (p100) limits nuclear translocation of NF-kappaB1-RelA and thereby functions as a regulatory 'brake' for the activation of naive T cells. |
